Selective deuterium substitutions play a role in altering the metabolism and absorption properties of drugs due to kinetic isotope effects. Alcohol compounds and their derivatives are important fragments for the synthesis of many active compounds. Therefore, we have reason to believe that the synthesis of deuterated alcohols is of great significance for deuterated drugs with improved safety and/or efficacy.

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Deuterium-labeled compounds have important research significance in the fields of organic synthetic chemistry, medicinal chemistry, and life sciences. In order to overcome the defects of poor metabolic stability and high toxicity of traditional pharmaceutical compounds, medicinal chemists from various countries have turned their hope to deuterated compounds.

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